Juniper Publishers - Does Intravitreal Bevacizumab Injection for Retinopathy of Prematurity Treatment Arrest Anterior Segment Development? - JOJ Ophthalmology

Juniper Publishers - Open Access Journal of JOJ Ophthalmology 

Authored by Joobin Khadamy

Purpose: To determine intravitreal bevacizumab (IVB) effect on ocular development by comparing refractive and biometric outcomes of intravitreal bevacizumab (IVB) and laser photocoagulation for treatment of retinopathy of prematurity (ROP).

Methods: A prospective nonrandomized interventional comparative study was conducted in a referral hospital for ROP management. All patients who received either single IVB or diode laser photocoagulation were enrolled. Cycloplegic refraction and biometry was performed before treatment and at the corrected age of 9 months.

Results: The IVB group included 17 patients (28 eyes; gestational age (GA): 28.54 ±2.2 weeks) and the laser group included 17 patients (34 eyes; GA: 28.53 ± 1.6 w). GA, BW and corrected age at the end of follow-up was statistically similar between the two groups. Eyes in IVB group had significantly longer axial lengths and thinner lenses at final visit (p=.037 and p=.002).

Conclusions: Following IVB treatment of ROP, eye development in general and crystalline lens in particular are less affected compared to laser treatment. This supports the idea that anterior segment arrest which was first described for laser therapy of ROP occurs minimally with IVB if at all.

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